Histone deacetylase: A potential therapeutic target for ovarian dysfunction.
نویسندگان
چکیده
Post-partum uterine disorders and reproductive tract infections cause ovarian dysfunction and infertility. Histone deacetylases (HDACs) prevent the relaxation of chromatin, and positively or negatively regulate transcription. Hence, HDACs play a pivotal role in altering the gene expression that impact different signalling pathways underling ovarian dysfunction. Thus, HDAC inhibitors (HDACi) may act as potential therapeutic targets in the treatment of an array of disorders impacting ovarian function.
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ورودعنوان ژورنال:
- Frontiers in bioscience
دوره 23 شماره
صفحات -
تاریخ انتشار 2018